Cell Motility Factors

Auteur: I. Goldberg
Taal: Engels
Cell Motility Factors
  • Engels
  • Hardcover
  • 9783764325695
  • Druk: 1991 ed.
  • juli 1991
  • 227 pagina's
Alle productspecificaties

Samenvatting

Cell motility is an important component of many basic physiologic and pathologic processes. Understanding mechanisms of cell motility is therefore essential to the development of new research and clinical approaches in biomedical research. In the early phases of embryogenesis, prepreogrammed morpho- genetic movement determines normal development. The migration of the neural crest cells, for example, is responsible for the establishment of almost the entire peripheral nervous system, the proper positioning of the epinephrine-secreting cells in the adrenal gland and the deposition of pigment cells in the skin (Newgreen and Erikson, 1986). Any distur- bance or deviation from this complex migration pattern results in serious malformations. The embryonic cells are stimulated to migrate by internal signals as well as by signals from adjacent cells. Various stimulatory and inhibitory mechanisms are likely to operate during this dynamic process. However, once morphogenesis is achieved, most so- matic cells tend to remain stationary, and the motile phenotype is dormant. Under certain physiologic and pathologic conditions, however, cells re-express their motile phenotype and migrate. In wound healing and angiogenesis cell migration and proper three-dimensional positioning is critical. Endothelial cell migration following luminal injury is another homeostatic mechanism which helps prevent vascular lesions (Reidy and Silver, 1985; Sholley et aI., 1977; Wong and Gottlieb, 1988). In pathological conditions such as atherosclerosis, smooth muscle cell migration through the internal elastic lamina to the luminal surface may be the initial event leading to the development of the atherosclerotic plaque (Goldberg, 1982).

Productspecificaties

Inhoud

Taal
Engels
Bindwijze
Hardcover
Druk
1991 ed.
Verschijningsdatum
1991-07-01
Aantal pagina's
227 pagina's
Illustraties
Nee

Betrokkenen

Auteur
I. Goldberg Israel Goldberg
Co-auteur
Israel Goldberg
Redacteur
Itzhak D. Goldberg
Uitgever
Birkhauser Verlag Ag

EAN

EAN
9783764325695

Overige kenmerken

Extra groot lettertype
Nee
NUR code
910
Oorspronkelijke releasedatum
1991-07-01
Thema Subject Code
GT

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