6-APA Production by Free and Agar Immobilized Bacteria Concepts in microbial bio-conversion of penicillins

Auteur: Sanjoy Das
Taal: Engels
6-APA Production by Free and Agar Immobilized Bacteria
  • Engels
  • Paperback
  • 9783659160455
  • juli 2012
  • 136 pagina's
Alle productspecificaties

Samenvatting

- Lactam antibiotics, in particular penicillins and cephalosporins have the annual sales of 65% of the total antibiotics market. Therefore the annual expenditure of penicillin G acylase (PGA) is estimated to be in the range of 10-30 million tons. PGA immobilization preparations (both enzyme and cells) to successfully produce 10,000 tons of total 6-aminopenicillanic acid (6-APA) provide a novel direction to the antibiotics industries promoting a safer and cleaner environment. In the present study, different bacterial samples were isolated from soil of different places of Dibrugarh and screened for biotransformation ability to produce 6-APA. Among ten of them, three gram positive bacterial samples designated as AKDD-2, AKDD-4 and AKDD-6 showed the production of 6-APA from penicillin G. Assessment of 6-APA production after incubation in penicillin G (2mg/ml) by three different samples separately in free and agar immobilization state was done by HPLC analysis. Reusability of immobilized cell was found successful up to 14 days. The work focuses comparison of catalytic properties to produce 6-APA of some industrially valuable soil microorganisms entrapped in agar with the free form."

Productspecificaties

Inhoud

Taal
Engels
Bindwijze
Paperback
Verschijningsdatum
2012-07-31
Aantal pagina's
136 pagina's
Illustraties
Nee

EAN

EAN
9783659160455

Overige kenmerken

Extra groot lettertype
Nee
NUR code
879
Oorspronkelijke releasedatum
2012-07-31
Subtitel
Concepts in microbial bio-conversion of penicillins
Thema Subject Code
MKG

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