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When a neighbor man molests young Zoe, a pseudo hermaphrodite and ugly duckling, she gains the means to build her first laboratory to explore microbes, eventually eliminating the predator and realizing her passion for using her tiny "friends" to murder those that persecute, harm, and threaten her. On a trip to Paris, she meets a man connected to the global underworld, and they create a company that provides terrorists the tools to eliminate their enemies. As a urologist affiliated with a prestigious New York hospital, Zoe privately continues to use her micro-friends to exact justice.
Heartbroken by her infertility, Zoe finds her world unravel when her husband's affair produces a child. When Zoe murders her husband's lover, her one careless misstep launches an investigation that spans Key West, New York, Panama, and the Grand Caymans. To stop her from unleashing her deadly microbes, the NYPD, FBI, and other agencies locate her lab and attempt to ensure that New York residents do not become the next victims in this woman's deadly game.