Eicosanoids and Radiation

Auteur: Onbekend
Taal: Engels
Eicosanoids and Radiation

Samenvatting

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car­ cinoma. Since that time, the concept that arachidonic acid metabolites may be in­ volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec­ tively. Cyclooxygenase products consist of diverse products such as prosta­ glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros­ taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
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Inhoud

Taal
Engels
Bindwijze
Paperback
Druk
Softcover reprint of the original 1st ed. 1988
Verschijningsdatum
2012-01-22
Aantal pagina's
196 pagina's
Illustraties
Nee

Betrokkenen

Auteur
Onbekend
Redacteur
Peter Polgar
Uitgever
Springer-Verlag New York Inc.

EAN

EAN
9781461289708

Overige kenmerken

Extra groot lettertype
Nee
Oorspronkelijke releasedatum
2012-01-22

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