Expression Profile of the Angiogenesis Inhibitor Vasohibin State of research, expression and regulation in the human heart

Taal: Engels
Expression Profile of the Angiogenesis Inhibitor Vasohibin
  • Engels
  • Paperback
  • 9783639292152
  • september 2010
  • 80 pagina's
Alle productspecificaties

Samenvatting

Vasohibin was recently isolated as an angiogenesis inhibitor, whose expression was augmented in endothelial cells by stimulation of vascular endothelial growth factor (VEGF) - the most crucial stimulator of angiogenesis, thus indicating its role as negative feedback regulator. Both animal studies and clinical trials have shown the potential positive benefit of VEGF for the revascularization after myocardial ischemia. The expression of vasohibin in the human heart, which could possibly influence the VEGF-mediated stimulation of angiogenesis, however, was so far unknown. Therefore we investigated the expression and regulation of vasohibin-1 in the human heart. We could show that vasohibin-1 was present in the human heart and that it was predominantly expressed in the nuclei and cytoplasms of cardiac cells. Furthermore, anoxia inhibited the vasohibin-1 expression in human adult cardiac myocytes. We therefore suggest that vasohibin-1 might interfere with current angiogenic therapies. The presence of the protein in the nucleus and the fact, that its mechanism of action is so far unknown, raises a lot of questions, that should be implicated in future studies.

Productspecificaties

Inhoud

Taal
Engels
Bindwijze
Paperback
Verschijningsdatum
2010-01-01
Aantal pagina's
80 pagina's
Illustraties
Nee

Betrokkenen

Auteur
Adrian Johannes Dorfner
Uitgever
Vdm Verlag

EAN

EAN
9783639292152

Overige kenmerken

Extra groot lettertype
Nee
NUR code
879
Oorspronkelijke releasedatum
2010-09-05
Subtitel
State of research, expression and regulation in the human heart
Thema Subject Code
MB

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