Insulin-Mimetic Studies on the Oxovanadium(iv) Complexes Glucose uptake effect of Schiff base complexes of oxovanadium(IV)

Auteur: Adeola Nejo
Taal: Engels
Insulin-Mimetic Studies on the Oxovanadium(iv) Complexes
  • Engels
  • Paperback
  • 9783848445462
  • april 2012
  • 208 pagina's
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Samenvatting

The isolation of the unsymmetrical Schiff bases posed some challenges. Majority of unsymmetrical Schiff bases reported in the literature were synthesized via a stepwise approach. There are only a few procedures which proceed via a one-pot condensation approach because the introduction of different carbonyl groups might lead to the formation of a mixture of products. But by fine-tuning some of the reaction conditions we were able to isolate the desired unsymmetrical Schiff bases at room temperature. The new synthetic procedure for the preparation of the unsymmetrical Schiff bases was developed in our laboratory. The isolation of the unsymmetrical Schiff bases and their VO(IV) complexes as well as some of the symmetrical Schiff bases and their complexes generated in this research work was considered to be novel. The in vitro and in vivo insulin-mimetic studies show that majority of the Schiff base complexes of VO(IV) were active and two of the complexes were as active or more active than insulin. The new results generated in this work significantly advance scientific knowledge and make a useful contribution in the area of insulin-mimetic studies.

Productspecificaties

Inhoud

Taal
Engels
Bindwijze
Paperback
Verschijningsdatum
2012-04-27
Aantal pagina's
208 pagina's
Illustraties
Nee

Betrokkenen

Auteur
Adeola Nejo Adeola Nejo
Co-auteur
Adeola Nejo
Uitgever
Lap Lambert Academic Publishing

EAN

EAN
9783848445462

Overige kenmerken

Extra groot lettertype
Nee
NUR code
913
Oorspronkelijke releasedatum
2012-04-27
Subtitel
Glucose uptake effect of Schiff base complexes of oxovanadium(IV)

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