p53 Protocols

p53 Protocols
Auteur: Deb, Sumitra
Uitgever: Humana Press Inc.
  • Engels
  • Paperback
  • 9781617373619
  • Druk: Softcover reprint of hardcover 1st ed. 2003
  • oktober 2010
  • 280 pagina's
Alle productspecificaties

Samenvatting

Since the discovery of p53 as a tumor suppressor, numerous methods have evolved to reveal the unique structural features and biochemical functions of this protein. Several unique properties of p53 posed a challenge to understa- ing its normal function in the initial phase of its research. The low levels of p53 in normal cells, its stabilization under situations of genotoxic stress, induction of growth arrest, and apoptosis with stabilization of the protein, obstructed the visibility of its normal, unmutated function. The property of p53 that can sense a promoter and transactivate or inhibit is still not well understood. It is still not known whether it is the absence of the protein that causes tumorigenesis, or if its mutants have a dominant role in inducing cancer. p53 Protocols comprises eighteen chapters for the study of the diverse properties of p53 and related proteins. The methods included are invaluable for delineating the function of other proteins that may function as tumor suppr- sors or growth suppressors. The chapters are not presented in any schematic order, for the importance and diversity of the functions of p53 make it imp- sible to organize them suitably. We have made a sincere effort to collect the methods most useful to those investigators working on tumor suppressors or growth suppressors. The purpose of p53 Protocols is not only to provide investigators with methods to analyze similar biochemical functions, but also to familiarize them with the associated problems that arose during the course of investigations.

Productspecificaties

Inhoud

Taal
Engels
Bindwijze
Paperback
Druk
Softcover reprint of hardcover 1st ed. 2003
Verschijningsdatum
2010-10-28
Aantal pagina's
280 pagina's
Illustraties
Nee

Betrokkenen

Auteur
Deb, Sumitra
Redacteur
Sumitra Deb
Uitgever
Humana Press Inc.

EAN

EAN
9781617373619

Overige kenmerken

Extra groot lettertype
Nee
Oorspronkelijke releasedatum
2010-10-28
Thema Subject Code
PSF

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Taal
Engels
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Onderwerp
Biologie, Levenswetenschappen
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