Resistance to Aromatase Inhibitors in Breast Cancer

Resistance to Aromatase Inhibitors in Breast Cancer
  • Engels
  • Paperback
  • 9783319382845
  • Druk: Softcover reprint of the original 1st ed. 2015
  • oktober 2016
  • 288 pagina's
Alle productspecificaties

Samenvatting

Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

Productspecificaties

Inhoud

Taal
Engels
Bindwijze
Paperback
Druk
Softcover reprint of the original 1st ed. 2015
Verschijningsdatum
oktober 2016
Aantal pagina's
288 pagina's
Illustraties
Nee

Betrokkenen

Redacteur
Alexey Larionov
Uitgever
Springer International Publishing Ag

EAN

EAN
9783319382845

Overige kenmerken

Extra groot lettertype
Nee
Thema Subject Code
MJCL

Je vindt dit artikel in

Categorieën
Taal
Engels
Studieboek of algemeen
Algemene boeken
Onderwerp
Biologie, Levenswetenschappen, Geneeskunde
Boek, ebook of luisterboek?
Boek
Nog geen reviews
Bindwijze: Paperback
150 99
Verwacht over 7 weken Tooltip
Verkoop door bol.com
  • Gratis verzending
  • 30 dagen bedenktijd en gratis retourneren
  • Ophalen bij een bol.com afhaalpunt mogelijk
  • Dag en nacht klantenservice