Top Drugs Top Synthetic Routes
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Uitgever: Oxford University Press
Auteur:
John Saunders
- Engels
- Paperback
- 9780198501008
- 18 mei 2000
- 96 pagina's
Samenvatting
This title allows students to see how the organic chemistry taught in undergraduate courses is applied by medicinal chemists in industry. This book describes briefly how each drug works and then reviews the most efficient routes to their synthesis.
Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.
Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.
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Inhoud
- Taal
- en
- Bindwijze
- Paperback
- Oorspronkelijke releasedatum
- 18 mei 2000
- Aantal pagina's
- 96
- Illustraties
- Nee
Betrokkenen
- Hoofdauteur
- John Saunders
- Hoofduitgeverij
- Oxford University Press
- Co Uitgever(s)
- Secondary
Overige kenmerken
- Editie
- illustrated edition
- Extra groot lettertype
- Nee
- Product breedte
- 190 mm
- Product hoogte
- 9 mm
- Product lengte
- 245 mm
- Studieboek
- Ja
- Verpakking breedte
- 188 mm
- Verpakking hoogte
- 245 mm
- Verpakking lengte
- 245 mm
- Verpakkingsgewicht
- 205 g
EAN
- EAN
- 9780198501008
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