Lead Generation Approaches in Drug Discovery
Afbeeldingen
Sla de afbeeldingen overArtikel vergelijken
- Engels
- Hardcover
- 9780470257616
- 09 april 2010
- 296 pagina's
Samenvatting
An integrated overview of modern approaches to lead discovery
Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including:
-
The evolution of the lead discovery process, key concepts, current challenges, and future directions
-
Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process
-
Knowledge-based in silico or "virtual" screening
-
Theory and practice of the fragment-based approach to lead discovery
-
The opportunities and challenges presented by multi-target drug discovery (MTDD)
-
De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules
-
The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space
-
Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery
-
The utility of parallel synthesis and purification in lead discovery
With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
An integrated overview of modern approaches to lead discovery
Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including:
-
The evolution of the lead discovery process, key concepts, current challenges, and future directions
-
Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process
-
Knowledge-based in silico or "virtual" screening
-
Theory and practice of the fragment-based approach to lead discovery
-
The opportunities and challenges presented by multi-target drug discovery (MTDD)
-
De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules
-
The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space
-
Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery
-
The utility of parallel synthesis and purification in lead discovery
With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.
Productspecificaties
Inhoud
- Taal
- en
- Bindwijze
- Hardcover
- Oorspronkelijke releasedatum
- 09 april 2010
- Aantal pagina's
- 296
- Illustraties
- Nee
Betrokkenen
- Hoofdauteur
- Zoran Rankovic
- Tweede Auteur
- Richard Morphy
- Co Auteur
- Richard Morphy
- Hoofduitgeverij
- Wiley-Blackwell
Overige kenmerken
- Editie
- 1
- Extra groot lettertype
- Nee
- Product breedte
- 162 mm
- Product hoogte
- 21 mm
- Product lengte
- 242 mm
- Studieboek
- Nee
- Verpakking breedte
- 165 mm
- Verpakking hoogte
- 25 mm
- Verpakking lengte
- 254 mm
- Verpakkingsgewicht
- 567 g
EAN
- EAN
- 9780470257616
Je vindt dit artikel in
- Taal
- Engels
- Boek, ebook of luisterboek?
- Boek
- Studieboek of algemeen
- Algemene boeken
Kies gewenste uitvoering
Prijsinformatie en bestellen
Rapporteer dit artikel
Je wilt melding doen van illegale inhoud over dit artikel:
- Ik wil melding doen als klant
- Ik wil melding doen als autoriteit of trusted flagger
- Ik wil melding doen als partner
- Ik wil melding doen als merkhouder
Geen klant, autoriteit, trusted flagger, merkhouder of partner? Gebruik dan onderstaande link om melding te doen.