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A Clinician's Introduction to the Immune Basis of Mental Disorders
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Oxford University Press
Oxford University Press had its origins in the information technology revolution of the late fifteenth century, which began with the invention of printing from movable type. The first book was printed in Oxford in 1478, only two years after Caxton set up the first printing press in England.
Despite this early start, the printing industry in Oxford developed in a somewhat haphazard fashion over the next century. It consisted of a number of short-lived private businesses, some patronized by the University. But in 1586 the University itself obtained a decree from the Star Chamber confirming its privilege to print books. This was further enhanced in the Great Charter secured by Archbishop Laud from King Charles I, which entitled the University to print 'all manner of books'.
The University established its right to print the King James Authorized Version of the Bible in the seventeenth century. This Bible Privilege formed the basis of a profitable business throughout the next two centuries and was the spur to OUP's expansion. A Bible warehouse was set up in London, which later grew into a major publisher of books with educational or cultural content aimed at the general reader. OUP then began to expand internationally, starting with the opening of an American office in 1896.
Oxford's traditions of religious and academic publication were followed in New York. The first book published by the American office was the Scofield Reference Bible in 1909. After it came The Life of Sir William Osler, which won the Pulitzer Prize in 1926. Six more Pulitzers, several National Book Awards, and over a dozen Bancroft Prizes in American history have followed since.
Since 1896, the business has changed considerably, with the growth and evolution of schools' publishing, particularly in the Branches; the introduction of English Language Teaching, Music, Journals, and Trade and General publishing; and the use of new technologies.
In recent years, a dedicated effort has been made to understand the immune dysfunction that is associated with major psychiatric disorders. The expanding knowledge of the immune system as a major homeostatic system has been very helpful in indicating new potential biomarkers and therapeutic targets to reduce the burden of psychiatric disorders. Indeed, immune cells, their secreted molecules, and cell signalling events are highly promising. Yet, the literature on immunology of psychiatric disorders is still dispersed, and only a few attempts have been made to consolidate the current knowledge in this expanding area. This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice. An international team of senior experts in the field review all psychiatric disorders in order to provide an integrated, in-depth understanding of the role of immune changes in psychiatric diseases for mental health clinicians as well as for researchers in immunology, psychiatry, neurology, and pharmacology.
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