Protein - Water Interactions A Differential Approach

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  • Engels
  • Paperback
  • 9781634630078
  • 01 december 2014
  • 78 pagina's
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Samenvatting

This book is aimed at understanding which molecular parameters control the thermodynamics, structure, and functions of the protein-water systems. Proteins are one of the most important classes of biological molecules. Water binding (hydration or biological water) plays a crucial role in determining the structure, stability, and functions of proteins. Knowledge of processes occurring upon hydration or dehydration of protein macromolecules is very important in biotechnological and pharmaceutical applications of proteins such as their use as biocatalysts, biosensors, and selective adsorbents. There are essential differences between hydration and bulk water surrounding a protein. This means that a characterisation of the hydration of protein macromolecules requires elucidating the effects of both the protein on water and vice versa. Therefore, a quantitative estimation of the protein and water contributions to the thermodynamic functions of binary protein-water systems is of considerable fundamental importance and practical interest. This book describes the basic principles of a novel methodology to investigate the protein-water interactions. This methodology is based on the analysis of the excess thermodynamic functions of mixing. The thermodynamic properties (volume V, enthalpy H, entropy S, heat capacity Cp, and Gibbs free energy G) of a real binary water-protein system can be expressed in terms of the excess functions. They are the difference between the thermodynamic function of mixing in a real system and the value corresponding to an ideal system at the same temperature, pressure and composition. For an ideal system, all excess functions are zero. Deviations of the excess functions from zero indicate the extent to which the studied binary system is non-ideal due to strong specific interactions between components (ie: hydrogen bonding and charge-charge interactions).

Productspecificaties

Inhoud

Taal
en
Bindwijze
Paperback
Oorspronkelijke releasedatum
01 december 2014
Aantal pagina's
78
Illustraties
Nee

Betrokkenen

Hoofdredacteur
Vladimir A Sirotkin
Hoofduitgeverij
Nova Science Publishers Inc

Overige kenmerken

Extra groot lettertype
Nee
Product breedte
159 mm
Product hoogte
13 mm
Product lengte
235 mm
Studieboek
Ja
Verpakking breedte
155 mm
Verpakking hoogte
230 mm
Verpakking lengte
230 mm
Verpakkingsgewicht
222 g

EAN

EAN
9781634630078

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