Retrograde Cellular Transport of Herpes Simplex Virus Interactions between Viral and Motor Proteins - a Gene Therapy Vector for Spinal Cord Disease?

Name: Retrograde Cellular Transport of Herpes Simplex Virus
Author: Mark Douglas

Auteur: Mark Douglas

Taal: Engels

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Auteur: Mark Douglas

Engels
Paperback
9783639028652
16 mei 2008
180 pagina's

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Mark Douglas

"Mark Douglas is also author of ""The Disciplined Trader™:Developing Winning Attitudes"" published in 1990 and considered an industry classic--and one of the first books to introduce the investment industry to the concept of trading psychology. Mark began coaching traders in 1982, and has continued to develop seminar and training programs on trading psychology for the investment industry, as well as individual traders. He has been a frequent speaker at seminars across the world, as well as in the U.S., teaching traders how to become consistently successful. He is currently working on his third book, and can be reached through his website markdouglas.com."

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Herpes simplex virus type 1 (HSV-1) establishes life-long latent infection in sensory neurones, making it an ideal gene therapy vector to target neuronal cells. To study retrograde transport of HSV-1, capsid and tegument proteins were tested for interactions with the motor cytoplasmic dynein, using a yeast two-hybrid system and in vitro pull down assays. A strong interaction was demonstrated between the HSV-1 outer capsid protein VP26 (UL35) and the homologous 14 kDa dynein light chains RP3 and Tctex1. The functional importance of VP26 for retrograde transport was confirmed by microinjecting recombinant HSV-1 capsids into living cells. Capsids containing VP26 moved closer to the cell nucleus, while capsids without VP26 remained in a random distribution. Our results suggest that the HSV-1 outer capsid protein VP26 mediates binding of incoming capsids to the retrograde motor cytoplasmic dynein during cellular infection, through interactions with dynein light chains. It is hoped that these findings will help in the development of a synthetic viral vector, which may allow targeted gene therapy in patients with neurological diseases.

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Taal: en
Bindwijze: Paperback
Oorspronkelijke releasedatum: 16 mei 2008
Aantal pagina's: 180
Illustraties: Nee

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Hoofdauteur: Mark Douglas
Hoofduitgeverij: Vdm Verlag Dr. Mueller E.K.

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Extra groot lettertype: Nee
Product breedte: 152 mm
Product hoogte: 10 mm
Product lengte: 229 mm
Studieboek: Ja
Verpakking breedte: 152 mm
Verpakking hoogte: 11 mm
Verpakking lengte: 229 mm
Verpakkingsgewicht: 249 g

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EAN: 9783639028652

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Categorieën: Wetenschap & Natuur

Geneeskunde & Verpleging

Geneeskunde algemeen

Biologie

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Taal: Engels
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Studieboek of algemeen: Algemene boeken

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