According to WHO data, in 2014, more than 1.9 billion (39%) of adults aged 18 and older have an overweight (OW). Of this number there are more than 600 million (13%) people suffering from obesity. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome closely associated with OW, insulin resistance. Morphological component of NAFLD is the triglycerides delaying in hepatocytes and the following lipid atherogenic changes. NAFLD and OW lead to compensatory hemodynamic changes of vascular structural and functional characteristics and further development of cardiovascular diseases. Gender indicator has a significant impact on the cardio-vascular risk due to the complexity of the system hormones. But gender factor is not the isolated risk leading to cardiovascular diseases if it not complemented by the other chronic diseases or chronic systemic abuses. Age-related changes also carry the load on the vascular structure when in a later age period the atherogenic risk of cardio-vascular pathology is increased. Ultrasound marker of subclinical atherosclerosis is an intima media thickness (IMT) and hemodynamic data of main neck arteries.