Ovarian Cancer Transmesothelial Migration Individual Cell-Based Model for Single Cells and Spheroids Invasion

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  • Engels
  • Paperback
  • 9783848481286
  • 27 april 2012
  • 148 pagina's
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Samenvatting

Ovarian cancer is the leading cause of death among gynecological malignancies. The high mortality rate is essentially due to cell ability to cross the mesothelial lining of the peritoneum and form widespread metastasis. This book illustrates a mathematical model able to reproduce in vitro transmesothelial migration assays of ovarian cancer cells, both isolated and aggregated in multicellular spheroids. The model integrates: (a) an Extended Cellular Potts Model (CPM), that captures mechanisms of cellular adhesion, shape constraints and motion; (b) a continuous model for the diffusion of chemoattractants; (c) a continuous model for matrix metalloproteinases released by tumor cells. The results predicted are in good agreement with biological experiments and they point out the principal biological phenomena and their influence on the overall process of invasion. This analysis could help understanding the potentiality of mathematical models in predicting cellular behaviors and should be especially useful to biologists that want to have a look into possible tools to enhance their researches and to mathematicians interested in applying their knowledge to biological systems

Productspecificaties

Inhoud

Taal
en
Bindwijze
Paperback
Oorspronkelijke releasedatum
27 april 2012
Aantal pagina's
148
Illustraties
Nee

Betrokkenen

Hoofdauteur
Chiara Giverso

Overige kenmerken

Extra groot lettertype
Nee
Product breedte
152 mm
Product hoogte
9 mm
Product lengte
229 mm
Studieboek
Ja
Verpakking breedte
152 mm
Verpakking hoogte
9 mm
Verpakking lengte
229 mm
Verpakkingsgewicht
227 g

EAN

EAN
9783848481286

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